A role of glycine transporter on spinal dorsal horn neuron through the pain sensation produced by neuropathic pain model

我们研究了甘氨酸转运体在脊髓背角神经元中的作用，但没有发现这种作用。因此，我们证明d-丝氨酸在脊髓背角神经元中具有两种不同的作用，一种是由NMDA受体介导的兴奋作用，另一种是由甘氨酸受体介导的抑制作用。有趣的是，d-丝氨酸在周围神经损伤后的兴奋作用比生理条件下更敏感，而其在周围神经损伤后的抑制作用比未损伤的小。

We investigated the effect of glycine transporter in spinal dorsal horn neuron, but we could not find that effect. Therefore, we have demonstrated that d-serine in spinal dorsal horn neuron has two distinct actions, one is an excitatory action mediated by NMDA receptor, the other is an inhibitory action mediated by glycine receptor. Interestingly, the excitatory action by d-serine after peripheral nerve injury was more sensitive than physiological condition, whereas its inhibitory action after peripheral nerve injury was less than naive one.