Application to the clarification and treatment of endoplasmic reticulum stress related the retinal pigment epithelium cells in Age-related macular degeneration.

内质网（ER）是细胞内重要的细胞器，负责蛋白质的合成和折叠。已有研究表明，内质网应激与糖尿病视网膜病变和老年性黄斑变性（AMD）有关。ER应激可引起RPE细胞蛋白表达增加和紧密连接跨上皮电阻增加，提示ER应激可改变RPE细胞功能，可能参与AMD的发病机制。

The endoplasmic reticulum(ER) is an important intracellular organelle responsible for the biosynthesis and folding of proteins. It has been reported that ER stress has been linked to the diabetic retinopathy and age-related macular degeneration(AMD). Increased protein expressions and transepithelial electrical resistance of tight junctions by ER stress in RPE cells indicate that ER stress can alter the function of RPE cells and may be involved in the pathogenesis of AMD.