The role of lipid-mediated intercellular communications in neuronal circuit development and regeneration

轴突沿着正确的路径生长对于神经元回路的形成是必要的。我们发现了轴突导向脂质分子溶血磷脂酰葡萄糖苷（LysoPtdGlc），鉴定了它的受体和下游信号通路，阐明了它在脊髓感觉轴突束形成中的功能意义。与以前关于蛋白质作为轴突引导线索的研究相反，他们的项目证明了脂质介导的轴突引导在神经元回路形成中的重要性

Axon growth along the correct path is necessary for neuronal circuit formation. We have discovered the axon-guiding lipid molecule Lysophosphatidylglucoside (LysoPtdGlc), identified its receptor and downstream signaling pathway, and elucidateid its functional significance in the spinal sensory axon tract formation. In contrast to previous studies on the role of proteins as axon guidance cues, thei project has demonstrated the importance of lipid-mediateid axon guidance in neuronal circuit formation