Raman Imaging with single molecules sensitivity and spatial resolution to elucidate catalytic reaction at solid-liquid interface

(1)通过控制与染料、DNA碱基、硫醇等靶分子的相互作用，实现纳米级的拉曼成像；(2)采用悬臂梁预热和原子力显微镜相结合的方法制备TERS探针，为银岛膜上的PATP提供明显的信号。采用悬臂梁预热和原子力显微镜模式制备TERS探针的方法，为银岛膜上的PATP提供了明显的信号。总而言之，我们的项目非常有效地进行了纳米RAMA成像。

We have investigated to realize nano-Raman imaging on:(1) flocculation method to fabricate closely adjacent Ag and Au nanoparticles by controlling the interaction with target molecules such as dye, DNA bases and thiols, which provided single molecule sensitivity using gap mode plasmons,(2) fabrication method of TERS probes using pre-heating of cantilever and AFM mode, which provided pronounced TERS signal for PATP on Ag island films. Conclusively, our projectproceeded quite efficiently towards nano-Rama imaging.(2) fabrication method of TERS probes using pre-heating of cantilever and AFM mode, which provided pronounced TERS signal for PATP on Ag island films. Conclusively, our projectproceeded quite efficiently towards nano-Rama imaging.