Analysis of the alteration of signal pathway in soft tissue sarcoma

我们证实了Akt-mTOR通路在平滑肌肉瘤、滑膜肉瘤、恶性周围神经鞘肿瘤、黏液纤维肉瘤、孤立性纤维瘤和皮肤纤维肉瘤中的激活。该通路的激活与这些肿瘤的组织病理恶性和不良预后相关。因此，Akt-mTOR通路可能是这些非小圆细胞肉瘤的候选分子靶点

We demonstrated the activation of Akt-mTOR pathway in leiomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath tumor, myxofibrosarcoma, solitary fibrous tumor and dermatofibrosarcoma protuberans. Activation of this pathway was correlated with histopathological malignancy and poor prognosis in these tumors. Therefore, Akt-mTOR pathway may be the candidate of molecular target in these non-small round cell sarcomas