Therapeutic strategy for the chronic pain through the neurogenesis of the central nervous system in enriched environment

我们的结果表明，暴露在丰富的环境中可以增强神经发生并调节情绪。丰富的环境通过持续的表观遗传修饰增加了小鼠海马区BDNF mRNA的表达。慢性疼痛过程通过皮质阿片受体的功能障碍促进扣带回的星形胶质细胞增生。此外，慢性疼痛抑制了丰富的环境介导的DCX和Neurd标记细胞的诱导。这些结果表明，慢性疼痛对海马神经发生具有应激样损伤调节作用。

Our results indicate that exposure to an enriched environment enhances neurogenesis and regulates emotionality. Enriched environment increases BDNF mRNA expression via sustained epigenetic modification in the mouse hippocampus. The chronic pain process promotes astrogliosis in the cingulate cortex through the dysfunction of cortical □-opioid receptors. Furthermore, chronic pain suppressed enriched environment mediated induction of both DCX- and NeuroD-labeled cells. These results suggest that chronic pain has stress-like damaging modulatory effects on hippocampal neurogenesis.