Basic study to unify periodontal medicine and anti-aging medicine

牙周病不仅是一种局部感染性疾病，而且对宿主来说是一种低级别炎症性疾病，它可以极大地影响糖耐量和心血管风险。因此，从分子基础上理解这一现象背后的机制对建立健康长寿具有重要意义。我们发现，牙周感染激活的免疫细胞迁移到脂肪组织，与脂肪细胞相互作用，从而增强免疫反应，影响脂质和葡萄糖代谢。这强烈表明，牙周治疗的目的不仅仅是为了避免拔牙，而是为了实现健康长寿。

Periodontal disease is not merely a local infectious disease, but also a low-grade inflammatory disease for the host which may greatly influences glucose tolerance as well as cardiovascular risk. Therefore, our understanding the mechanisms behind this phenomenon at molecular basis is important to establish healthy longevity. Here, we found activated immune cells by periodontal infection migrated into adipose tissues, interacted with adipocytes, thereby enhancing immune responses as well as influencing lipid and glucose metabolism. It is strongly indicataed that the purpose of periodontal treatment is not only to avoid tooth extraction, but also to achieve healthy longevity.