Comprehensive analysis of the molecules up- or down- regulataed in dental pulp cells co-cultured with macrophages

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Irreversible pulpitis often accompanies intolerable pain. Hoever, pulp preservation is an ideal goal of dental treatment to avoid unwanted side effects such as tooth fracture. To save dental pulp, development of adhesive materials achieving no microleakage and controling dental pulp tissue inflammation are two essential factors. This study dealt with latter issue. The purpose of this study was 1) to establish in vitro pulpitis model, 2) to explore the reagent controlling pulp inflammation and the compound carrying such reagent, and 3) to analyze molcules up- or down- regulated under inflammatory conditions in pulp cells. All these approaches contribute to develop new strategy aiming the preservation of pulp tissues. We found the reason why pulpal inflammation expands in a short period and leads to tissue necrosis. These findings are important in our understanding the patho-physiology of dental pulp inflammation.