Roles of monoaminergic and secretinergic regulations of synaptic transmission in cerebellar inhibitory synapses

在这项研究中，我们研究了单胺（去甲肾上腺素（NA）和多巴胺（DA））和分泌素的作用，利用大鼠小脑的突触传递。1)药理学研究表明，突触前α2-肾上腺素能受体（α2-AR）和D2-样受体（D2-like receptor，D2 R）均被NA和DA激活，因此认为这两种受体之间的相互作用是共享小脑中涉及不同单胺能控制的调节作用。2)众所周知，神经肽促胰液素增加GABA的释放，涉及激活cAMP-PKA信号级联到小脑皮层的抑制性突触。在GABA能突触终末发现了一种新的突触调制形式，它涉及到PLC-IP 3信号通路的激活。

In this study, we examined a role of monoamines (noradrenaline (NA) and dopamine (DA)) and secretin on the synaptic transmission using rat cerebellum. 1) Pharmacological study revealed that presynaptic α2-adrenergic (α2-AR) and D2-like receptors (D2R) were activated by both NA and DA. Therefore, it is thought that cross-talk between these receptors play a role of sharing the modulatory action involving distinct monoaminergic controls in the cerebellum. 2) It is well known that neuropeptide secretin increases GABA release involving an activation of cAMP-PKA signal cascade onto inhibitory synapses at the cerebellar cortex. We found that new form of synaptic modulation involving the activation ofPLC-IP3 signal pathway at GABAergic synaptic terminals.