Effects of general anesthetics on glucose metabolism in fed rats with hemorrhagic shock and ischemia/reperfusion

与七氟醚麻醉相比，异丙酚麻醉在有氧和无氧条件下都能促进胰岛素的分泌。β-胰岛细胞三磷酸腺苷敏感钾通道可能参与了七氟醚麻醉和异丙酚麻醉对胰岛素分泌的不同影响。异丙酚麻醉下的胰岛素分泌和胰岛素敏感性的变化与七氟醚麻醉下的明显不同。在异丙酚麻醉下的缺血/再灌注期间，胰岛素敏感性的变化似乎与血浆肿瘤坏死因子-α水平的变化有关。

When compared to sevoflurane anesthesia, propofol anesthesia enhances insulin secretion under aerobic as well as anaerobic conditions. It is probable that adenosine triphosphate-sensitive potassium channels in beta-islet cells are involved in the different effects of sevoflurane anesthesia and propofol anesthesia on insulin secretion. Changes in both insulin secretion and insulin sensitivity during ischemia/reperfusion under propofol anesthesia are markedly different from those under sevoflurane anesthesia. During ischemia/reperfusion under propofol anesthesia, changes in insulin sensitivity seemed to be correlated with changes in plasma tumor necrosis factor-alpha levels.