Nobel bone regenerative medicine promoted by regulation of human MSC by Wnt/sFRP family

近年来研究发现，Wnt信号通路调控人间充质干细胞（hMSCs）的成骨分化。我们利用Wnt拮抗剂sFRP-3调控这一信号通路，并在体外和体内研究了其对hMSCs成骨分化的影响。结果表明，在动物模型中，添加sFRP-3可使hMSCs早期分化和矿化，并表现出早期骨再生。这些发现表明利用sFRP-3进行骨再生医学的可能性。

Recently it has been revealed that Wnt signaling pathway regulates the osteoblastic differentiation of human mesenchymal stem cells (hMSCs). We used sFRP-3, the antagonist of Wnt, to regulate this signaling and investigated the effect on osteoblastic differentiation of hMSCs in vitro and in vivo. It was revealed that the addition of sFRP-3 showed early differentiation and mineralization of hMSCs, and also showed early bone regeneration in animal model. These findings indicated the possibility of novel bone regenerative medicine using sFRP-3.