Regeneration of mind : Development of a novel treatment of psychiatric disorder caused by nurturing environment such as child abuse

在啮齿类动物中，母亲分离（MS）是一种忽视模型，增加了抑郁和焦虑样行为以及成年后下丘脑-垂体-肾上腺对压力的反应。在这项研究中，我们分析了什么是MS最敏感的行为指标，以开发一种新的治疗方法。结果表明，MS能显著延长大鼠旷场实验中的贴壁行为持续时间，提示贴壁行为是一种新的抗焦虑药敏感性高的焦虑样行为。

In rodents maternal-separation(MS), which is a neglect model, increases depression-and anxiety-like behaviors and hypothalamic-pituitary-adrenal responses to stress in adulthood. In this study, we analyzed what is the most sensitive behavioral indicator of MS to develop a novel treatment. We found that MS increased markedly the duration of leaning-against-wall behavior in open field test in rats, and that the leaning-against-wall behavior was a new high sensitive anxiety-like behavior by using anxiolytic.