Functional analysis of ER stress sensor OASIS on the neuronal protection from the toxicity of kainic acid.

积累的证据清楚地表明，内质网应激参与了包括阿尔茨海默病在内的神经退行性疾病的发展。我们研究了星形胶质细胞特异表达的内质网应激感受器OASIS的功能。最近，我们建立了OASIS-/-小鼠，这表明海马区锥体神经元对海人酸毒性的易感性增加。在本研究中，我们发现在星形胶质细胞中表达的OASIS在脑源性神经营养因子(BDNF)的表达和分泌中发挥重要作用，从而保护神经元免受红藻氨酸的毒性。

Accumulated evidence clearly indicates that ER stress is involved in the development of neurodegenerative disorders including Alzheimer's disease. We have investigated the functions of ER stress sensor OASIS, which is specifically expressed in astrocyte. Recently, we established OASIS-/- mouse which shows the increased vulnerability of hippocampal pyramidal neurons to the toxicity of kainic acid. In this study, we found that OASIS expressed in astrocyte plays important roles on the expression and secretion of brain-derived neurotrophic factor (BDNF) to protect the neurons from the toxicity of kainic acid.