Generation of Diabetic model mouse using improved toxin receptor

以前我们用TRECK方法建立了糖尿病小鼠模型。该模型小鼠可以通过施用白喉毒素（DT）来确定何时发生糖尿病。我们也可以控制症状的程度。然而，即使没有DT治疗，转基因小鼠也显示出糖耐量和胰岛结构的异常。在本研究中，为了解决在模型小鼠中发现的这些问题，我们使用修饰的DT受体产生改进的TRECK糖尿病模型小鼠。新的糖尿病模型小鼠在DT治疗前显示正常的胰岛结构，在DT给药后它们出现高血糖。

Previously we generated the diabetic model mouse by using TRECK method. This model mouse can be determined when to develop diabetes by the administration of Diphtheria toxin (DT). We can also control the level of the symptom. However, the transgenic mouse displayed abnormality in glucose tolerance and islet structure even without DT treatment. In this study, to solve these problems found in the model mouse, we generated improved TRECK diabetic model mice using a modified DT receptor. The new diabetic model mice showed normal architecture of pancreatic islets before DT treatment and they developed hyperglycemia after DT administration.