DNA methylation and histone modification regulate differentiationof skeletal stem cells
DNA methylation and histone modification regulate differentiationof skeletal stem cells
批准号:
22390344
负责人:
NIFUJI Akira
金额:
$12.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
Chromatin structure is a critical determinant to regulate gene expression and it alters during fate decision or/and cell differentiation. Patterns of post-translational modification at histone tails as well as methylation patterns of cytosine residues at DNA affect chromatin structure. In this study, we examined histone modification during skeletal cell differentiation. We observed dynamic changes of expression of H3K9methyltransferases at H3K9 and localization of three H3K9 methylation patterns, me1, me2, and me3 , during skeletal development. It also suggests that nhibition of H3K9 me2 affects gene expression and subsequent cell differentiation.
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Extracellular modulators regulate Bone Morphogenic Proteins in skeletal tissue
细胞外调节剂调节骨骼组织中的骨形态发生蛋白
DOI:
--
发表时间:
2010
期刊:
J Oral Biosciences
影响因子:
--
作者:
[Nifuji A, Ideno H, Takanabe R, Noda M]
通讯作者:
Noda M
Collagen Gel Culture Accelerates Proliferation of Mouse Periodontal Ligament Cells.
胶原凝胶培养加速小鼠牙周膜细胞的增殖。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Shimada A, Shibata T, Komatsu K, Nifuji A]
通讯作者:
Nifuji A
A Molecular mechanisms of skeletal tissue formation.
A 骨骼组织形成的分子机制。
DOI:
--
发表时间:
2013
期刊:
J Physical Fitness and Sports Medicine.
影响因子:
--
作者:
[Morita J, Funato N, Kobayashi Y, Nakamura M, and Moriyama K, Nifuji]
通讯作者:
Nifuji
Nifuji A.The myogenic conversion from fibroblastsinto myogenic cells is blocked by Trichostatin A through suppression of myogenin expression
Nifuji A.曲古抑菌素 A 通过抑制肌生成素表达来阻断从成纤维细胞到肌原细胞的肌原性转化
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ideno H, Araki R,Imaizumi K, Abe M]
通讯作者:
Abe M
Ideno H, Nifuji A. Pre-incubation of whole teeth in collagen gel enrich progenitor cells of mouse periodontal ligament.
Iden H, Nifuji A. 在胶原凝胶中预孵育整颗牙齿可丰富小鼠牙周膜的祖细胞。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Shimada A, Shibata T, Komatsu K]
通讯作者:
Komatsu K
共 36 条
Cellular conversion from non- skeletal to skeletal cells by using transactivation MyoD domain
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批准号:25670784
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2013
-
负责人:NIFUJI Akira
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依托单位:
Epigenetic changes in cell fate decision during mesenchymal cell differentiation.
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批准号:23659862
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:NIFUJI Akira
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依托单位:
Molecular approaches to identify molecules involved in the cell aggregates formation in the skeletal blastema and elucidation of their functional properties
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批准号:19390475
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.23万
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财政年份:2007
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负责人:NIFUJI Akira
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依托单位:
Study on regulation of osteogenesis through BMP antagonists
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批准号:16390521
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.09万
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财政年份:2004
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负责人:NIFUJI Akira
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依托单位:
Search for key molecules in bone and cartilage differentiation
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批准号:13557153
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.68万
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财政年份:2001
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负责人:NIFUJI Akira
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依托单位:
Chondrocyte specific regulation by BMP inhibitors in a medsodermal stem cell C1 and skeletal cells
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批准号:13671895
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.92万
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财政年份:2001
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负责人:NIFUJI Akira
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依托单位:
Regulation of skeletal cell differentiation by BMP and its inhibitor, noggin
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批准号:11671836
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:1999
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负责人:NIFUJI Akira
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依托单位:
Molecular analysis of epithelial mesenchymal interaction during tooth formatio
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批准号:07557112
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$11.33万
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财政年份:1995
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负责人:NIFUJI Akira
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依托单位:
海外基金