Development of the ISVSr(irregular shaking and vibration stimulator) which is new physical therapy, and study of the content effective for the prevention of bone fracture by using it.

由于绝经后雌激素的下降，骨质疏松症对骨小梁有巨大的影响。目前的研究使用了一种去卵巢小鼠骨密度下降的模型来模拟绝经后的女性。通过平台旋转形式的刺激，研究了防止骨密度下降的物理疗法。骨组织形态计量学分析显示，腰椎骨密度的下降有所减轻，这是常规物理疗法无法达到的效果。对于具有双关节肌肉功能的肌肉，如腰大肌，在起始侧和起止侧的肌肉肥大、生成和分化方面存在差异。

The osteoporosis has a massive impact primarily on trabecular bone as a result of the postmenopausal decline in estrogen. The current study used a model of the decrease in bone density in ovariectomized mice to simulate postmenopausal women. Physical therapy to prevent a decrease in bone density was studied via stimulus in the form of rotation of a platform. Analysis of bone histomorphometry revealed lessening of the decrease in bone density of the lumbar vertebrae, a feat that the stimulus from conventional physical therapy had failed to achieve.With muscles that function as two-joint muscles such as the psoas major, differences exist in muscular hypertrophy, generation and differentiation between origin and insertion sides.