Formation and Application of Resorcinarene Hexameric Capsule with Chiral Cavity in Fluorous Solvent

利用含间苯二酚的手性助剂，在含氟溶剂中制备了一种具有手性腔的六聚氟间苯二酚胶囊。因此，用间苯二甲酸六聚体胶囊对客体分子进行了手性腔的对映选择性包封。当使用r构型的手性助剂作为取代基时，(S)-2,2 ' -二甲基-1,1 ' -联萘基作为客体分子被对映选择性地包封，并在含氟相中以高达76%的ee从胶囊中回收。也就是说，利用含氟溶剂的特性，封装的客体分子只能通过简单的分离进行分解。该胶囊可作为一种新型的溶解试剂。然而，这种方法的可重复性可能需要进一步改进。

A novel fluorous resorcinarene hexameric capsule with chiral cavity in fluorous solvent was realized by use of the resorcinarene bearing chiral auxiliary. Hence, enantioselective encapsulation of guest molecules using the resorcinarene hexameric capsule with chiral cavity was observed. When chiral auxiliary of R-configuration as a substituent was used, (S)-2,2’-dimethyl-1,1’-binaphthyl as a guest molecule was enantioselectively encapsulated and recovered in up to 76% ee from the capsule in fluorous phase. That is to say, encapsulated guest molecule could resolve only by simple separation based on utilizing the feature of fluorous solvent. This capsule could be a new type of resolving reagent. However, reproducibility in this method may need to improve more.