Bioorganic Studies on Neurotrophic Natural Products

我们对发现的四种具有神经营养作用的天然产物进行了生物有机化学研究。作为结果，完成了新维菌素的形式不对称合成，并阐明了其最小结构单元。合成了他老丁的所有七个立体异构体，提出了四个取代基都沉积在THP上的活性最高的异构体。此外，已发现新维菌素、他劳米丁和丁基丁烷二聚体能促进小鼠海马区的神经发生。此外，还成功地制备了新生物素活性衍生物的荧光和光亲和标记探针。

We have carried out bioorganic chemical studies on four neurotrophic natural products which we found. As results, formal asymmetric synthesis of neovibsanin has been completed, and also its minimum structure unit has been clarified. All seven stereoisomers of talaumdin have been synthesized, resulting in proposing the most active isomer in which all four substituents are deposited down on THP. Moreover, neovibsanin, talaumidin, and penylbutane dimer have been found to enhance neurogenesis in mouse hippocampus. In addition, both the fluorescent and photoaffinity labeling probes of neovibsanin active derivative have been successfully prepared.