Systemic neurodegeneration and involvement of astroglial cells in Parkinson's disease.

在本研究中，我们发现慢性鱼藤酮治疗大鼠回肠和升结肠的肌肠丛分布着gfap阳性的胶质细胞，在中枢多巴胺能神经变性之前，提示肠胶质细胞可能参与了鱼藤酮诱导的肠神经元细胞毒性，在中枢神经系统神经变性之前。利用原代培养细胞，我们还提出了鱼藤酮处理的中脑星形胶质细胞分泌的一些分子可能参与了鱼藤酮诱导的多巴胺能神经毒性，并揭示了金属硫蛋白可以保护多巴胺能神经元免受鱼藤酮毒性的影响。

In this study, we revealed that GFAP-positive glial cells were distributed along the myenteric plexus in the ileum and ascending colon of rotenone-chronically treated rats, preceding central dopaminergic neurodegeneration, suggesting possible involvement of enteric glial cells in rotenone-induced cytotoxicity of enteric neuronal cells which precedes neurodegeneration in central nervous system. Using primary cultured cells, we also proposed a possible involvement of some molecules secreted from rotenone-treated mesencephalic astroglia in rotenone-induced dopaminergic neurotoxicity, and revealed that metallothionein could protect dopaminergic neurons against rotenone toxicity.