Research on mechanism of progression from vasculitis of Kawasaki disease to sclerotic lesion

炎症、氧化应激和血管内皮紊乱与血管紊乱和动脉硬化的发生密切相关。它们启动各种细胞因子的产生和血小板活化，从而促进疾病的发展。我们检测了急性川崎病患者的血小板活化和氧化应激。IVIG反应组氧化应激和炎症指标在IVIG治疗后立即下降。另一方面，治疗前ivig -无应答组抗氧化指标显著低于健康对照组和ivig -有应答组，氧化应激和炎症指标维持较高水平。自川崎病发病起，血小板被激活超过6个月。本研究表明，氧化应激和血小板活化的评价是有用的，具有临床意义。

Inflammation, oxidative stress and vascular endothelial disorder related deeply the onset of vascular disorder and arteriosclerosis. They initiate production of various cytokines and platelet activation, thereby progress disease condition.We examined platelet activation and oxidative stress in acute Kawasaki disease. Oxidativestress and inflammatory markers in IVIG-responder group immediately decreased by IVIG treatment. On the other hand, antioxidant marker of IVIG-nonresponder group in pre-treatment was significantly lower than that of healthy control and IVIG-responder group, and oxidative stress and inflammatory markers maintained high value.Platelet was activated for more six months from the onset of Kawasaki disease. This study showed the evaluation of oxidative stress and activated platelets are useful and have clinical significance.