Evaluation of tight junctions under bacterial translocation for development of treatment

细菌转化下，炎症细胞因子的表现（TNFα，NF-κB等人）and Toll like receptor （TLR） 2， 4 were increased and caused apoptosis。紧结（TJ）蛋白质（Claudin-1和4，Ocludin等人）were decreased。微生物组的多样性已经消失，阿克曼氏症，是分散的肠道表皮，已经出现。草药医学（TU-100）退化的炎症细胞因子和TLR 2， 4和保留的TJ蛋白质和微生物组的多样性，受限制的Blautia对肠道表皮的保护性影响。

Under bacterial translocation, expressions of inflammatory cytokines (TNFα、NF-κB et al.) and Toll like receptor (TLR) 2, 4 were increased and caused apoptosis. Tight Junction (TJ) protein (Claudin-1・4、Occludin et al.) were decreased. Diversity of microbiome was decreased and Akkermansia, which disturbed intestinal epithelium, was appeared. Herbal medicine (TU-100) decreased inflammatory cytokines and TLR 2, 4 and maintained TJ proteins and diversity of microbiome, which intoruduced Blautia having protective effects of intestinal epithelium.