Strategy targeting neuropeptide receptors in the central and peripheral nervous systems in treatment of underactive bladder

对糖尿病基因突变小鼠（DM）的下尿路功能进行了评价，并与野生型小鼠进行了比较。提示糖尿病小鼠前脑控制排尿的机制缺乏相应的抑制功能，出现反射性排尿。30周龄DM小鼠的排尿效率仍保持在80%以上，尽管膀胱轻度活动不足。鞘内给药PACAP-38增加最大排尿压力，部分抑制外尿道括约肌活动，提示脊髓PACAP受体刺激可能增强膀胱收缩力，改善排尿效率。

Lower urinary tract function of genetically mutated mice with diabetes mellitus (DM) was evaluated and compared to that of the wild-type mice. The results suggest that in DM mice, mechanism controlling voiding in the forebrain is devoid of appropriate inhibitory function, and thus the animals present reflex micturition. DM mice at age of 30 week-old still retain voiding efficiency more than 80%, albeit moderately present underactive bladder. Intrathecal administration of PACAP-38 increased maximal voiding pressure and partially suppressed external urethral sphincter activity, suggesting the possibility that stimulation of spinal PACAP receptors enhancesbladder contractility and ameliorates efficiency for voiding.