Single cell Analysis of asymmetrical cell division of hematopoietic stem cell

从基因表达分析数据中，我们重点研究了Tie2在造血干细胞的子代细胞上的分布。Tie2在PDCs中的分布在稳定期呈不对称分布，在增殖状态下呈对称性分布。此外，Tie2配体Ang-1的刺激使细胞分裂模式向不对称方向转变。通过本研究可望对造血干细胞的操作分裂模式和干细胞扩增有一定的指导意义。

We focused on the distribution of Tie2 on the Pired Daughter Cells(PDCs) of hematopoietic stem cells from the gene expression analysis data. The distribution pattern of Tie2 to PDCs was asymmetrically on steady state, on the other hand, it was symmetrically on the proliferative condition. Moreover, it was suggested that stimulation of Tie2 ligand, Ang-1 shifted the cell division pattern to asymmetric. It will be expected that the operation of cell division pattern of hematopoietic stem cells and stem cell expansion from this research.