The mechanism of allo-grafted cell Rejection by Allo-Induced Macrophages

同种异体排斥反应的效应细胞是杀伤性T细胞（CTL）或NK细胞。然而，也有一些CTL不能产生某些同种异体排斥反应的事件被报道。我们已经表明，同种异体激活的巨噬细胞是一些同种异体排斥反应的主要效应。我们证实，同种异体细胞毒活性是更高的Mac-1阳性部分，这是一个表面标记的巨噬细胞，比在NK 1.1阳性部分的效应细胞通过排斥移植到腹腔的小鼠Meth A纤维肉瘤细胞。此外，从在体外用抗Meth A细胞的抗体后同种异体移植物的腹膜浸润细胞的细胞毒活性略高的事实获得的结果表明，活化的巨噬细胞是效应细胞。

The effector cells of allo-rejection has been to be killer T cells (CTL) or NK cells. However, several events which CTL cannot producing some allograft rejections have also been reported. We have shown that allo-activated macrophages are the major effector of some allograft rejections. We confirmed that the allo-cytotoxic activity is higher in Mac-1 positive fraction, which is a surface marker of macrophage, than in NK1.1-positive fraction of effector cells through the rejection of allo-grafted Meth A fibrosarcoma cells grafted into the abdominal cavity of mice. In addition, to obtain the results suggest that activated macrophage is the effector cell from the fact that the cytotoxic activity of peritoneal infiltration cell of allograft after slightly higher with antibodies against Meth A cells, in vitro.