Synthetic compounds to specifically activate or inhibit ryanodine receptor calcium ion channels

该项目的目的是开发合成化合物，特异性和可逆地激活或抑制ryanodine受体钙释放通道，从而增加或减少骨骼肌和心脏的力量。 这些化合物将可用于生物医学和兽医科学以及畜牧业。 一些对哺乳动物ryandine受体亚型无效的化合物可能与昆虫通道相互作用，并为一类新的杀虫剂提供模板。 所述化合物将基于天然存在的肽，所述肽特异性且可逆地调节哺乳动物钙通道。

The aim of the project is develop synthetic compounds that specifically and reversibly activate or inhibit ryanodine receptor calcium release channels, and will thus increase or reduce the force developed by skeletal muscle and the heart. The compounds will be useful in biomedical and veterinary sciences and in the livestock industry. Some of the compounds that are not effective on mammalian ryandine receptor isoforms might interact with insect channels and provide a template for a new class of insecticides. The compounds will be based on naturally occurring peptides which specifically and reversibly modulate mammalian calcium channels.