Synthetic study on bioactive natural product, causing hatching phenomenon toward potato Cyst nematodes, by construction of highly-substituted cyclobutane skeleton

对马铃薯孢囊线虫最具活性的孵化剂茄果菌素A的合成进行了研究，不仅对茄果菌素A的化学供应进行了研究，而且对茄果菌素A的构效关系进行了研究。结果发现了一种新的扩环反应，用于合成具有角甲基的手性六氢甘菊环骨架。此外，还合成了对应于左环的氧杂双环骨架。

Synthesis of solanoeclepin A, the most active hatching agent of potato cyst nematode isolated from hydroponic potato cultures was examined not only for the chemical supply of solanoeclepin A but also for the structure-activity relationship study. As a result, the new ring expansion reaction was discovered for the synthesis of a chiral hexahydroazulene skeleton possessing an angular methyl group. Furthermore, synthesis of oxabicylo skeleton, corresponding to the left-hand nucleus, was also achieved.