Regulation of immune state in adipose tissue associated with life style diseases by food components

本研究旨在阐明肥胖症发生发展过程中免疫细胞向脂肪组织浸润的情况，并探讨改善肥胖症脂肪组织免疫状态的食物成分。结果，T细胞和肥大细胞以及巨噬细胞浸润到肥胖脂肪组织中，我发现肥大细胞参与了肥胖脂肪组织的纤维化。我进一步证明了食物来源的类胡萝卜素，虾青素和黄质，可以通过抑制脂肪细胞分化来改善肥胖小鼠的葡萄糖耐受不良，从而抑制肥胖脂肪组织中免疫状态的恶化。

In the present study, I clarified the immune cells infiltrated into adipose tissues in the progression of obesity, and explored the food components which can improve the immune state in obese adipose tissues. As a result, T cells and mast cells, as well as macrophages, were infiltrated into obese adipose tissues, and I found the involvement of mast cells in fibrosis of obese adipose tissues. I further demonstrated that food-derived carotenoids, astaxanthin and canthaxanthin, could improve glucose intolerance in obese mice by the inhibition of adipocyte differentiation, which suppressed the aggravation of immune state in obese adipose tissues.