The role of opioid neurotransmission in pain-induced aversion

在目前的研究中，我们研究了终纹床核(BNST)内的阿片类药物在疼痛诱导的厌恶中的作用。联合注射阿片激动剂可逆转背外侧核内注射CRF引起的条件性位置厌恶(CPA)。另一方面，dlBNST内注射阿片激动剂也可改变痛刺激引起的伤害性行为。此外，我们发现BNST腹侧部分的去甲肾上腺素能传递调节食物摄入量和类似焦虑的行为。

In the present study, we examined the role of the opioid within the bed nucleus of the stria terminalis(BNST) in pain-induced aversion. The conditioned place aversion(CPA) induced by intra-dorsolateral part of BNST(dlBNST) injection of CRF was reversed by the co-injection of an opioid agonist. On the other hand, nociceptive behaviors induced by pain stimulus were also changed by intra-dlBNST injection of opioid agonist. Further, we revealed that noradrenergic transmission within the ventral part of BNST regulates food intake and anxiety-like behaviors.