Development of the method for prevention of dental caries with antibacterial ammonium hexafluorosilicate

氟化二胺银(Saforide)是临床上用于预防龋病进展和敏感牙脱敏的药物。不幸的是，二胺氟化银因银沉积而染黑牙齿。为了克服这一缺点，制备了六氟硅酸铵。六氟硅酸铵的抗菌活性似乎不如氟化二胺银。为了提高六氟硅酸铵的抗菌活性，在六氟硅酸铵溶液中添加了几种抗菌剂。加入抗菌剂后，六氟硅酸铵的抗菌活性增强，因此，六氟硅酸铵是一种有效的防龋剂。

Diamine silver fluoride (Saforide) is clinical use for prevent of progress of dental caries and desensitizing for hypersensitive tooth. Unfortunately, diamine silver fluoride stained tooth black due to silver deposition. To overcome this drawback, ammonium hexafluorosilicatewas prepared. Comparing the antibacterial activity, ammonium hexafluorosilicate seems to be inferior to diamine silver fluoride. To increase the antibacterial activity of ammonium hexafluorosilicate, several antibacterial agents have been added to ammonium hexafluorosilicate solution. The antibacterial activity of ammonium hexafluorosilicate with the addition of antibacterial agents was increased, therefore, ammonium hexafluorosilicate is useful for prevention of dental caries.