Analysis of inhibiting the invasion and metastasis in oral squamous cell carcinoma

本研究旨在通过激活KCNJ 2-Lin 7 C-CASK-βcatenin通路，建立一种抑制口腔鳞状细胞癌（OSCC）侵袭转移的新方法。由于βcatenin上游的KCNJ 2表达受到抑制，βcatenin表达水平增加。此外，我们还通过抗心律失常通路分析，鉴定了KCNJ 2上游的一些分子，并重点研究了治疗室性心动过速的药物胺碘酮。用该药物治疗后，Lin 7 C、CASK和βcatenin的表达水平显著上调。我们认为KCNJ 2的特异性抑制剂胺碘酮与KCNJ 2-Lin 7 C-CASK-βcatenin通路密切相关，因此可能成为肿瘤侵袭和转移的治疗药物。

The aim of this study was to develop a new method of inhibiting the invasion and metastasis of oral squamous cell carcinoma (OSCC) through the activating KCNJ2-Lin7C-CASK-βcatenin pathway. As the result of suppressed expression of KCNJ2 which located upstream of βcatenin, βcatenin expression levels were increased. In addition, we identified some molecules of upstream of KCNJ2 by the Ingenuity Pathway Analysis, and then focused amiodarone which is the drug of ventricular tachycardia. After treatment with this drug, expression levels of Lin7C, CASK and βcatenin were significantly up-regulated. We suggested that the specific KCNJ2 inhibitor, amiodarone, closely related to KCNJ2-Lin7C-CASK-βcatenin pathway, and therefore might be a therapeutic agent for cancer invasion and metastasis.