Development of the method of treatment for neuropathic pain -Basic study of the effect of iontophoresis-

本研究旨在比较交流离子透入（AC IOP）和直流离子透入（DC IOP）的效果。行为和免疫组织学实验结果表明，直流型IOP起效时间短，而AC IOP起效时间慢，起效时间长。根据利多卡因血药浓度的测定结果，我们证实这些影响不是由全身给药利多卡因引起的。此外，我们所施加的电力并没有导致埃文斯蓝在电极下的皮肤中外溢。因此，本研究结果提示AC IOP因其作用时间长，对慢性疼痛患者有用。

This study aimed to compare the effect of alternating current iontophoresis (AC IOP) with direct current iontophoresis (DC IOP). As a result of behavior and immunohistological experiment, DC IOP have a fast onset time and a short effect time, while AC IOP have a slow onset time and a long effect time. According to the result of the blood concentration of lidocaine, we confirmed that those effects were not caused by systemic administration of lidocaine. Additionally, those electrical powers we applied did not lead to extravasation of Evans Blue in the skins under the electrodes.Thus, these findings of this study suggest that AC IOP is useful for patients suffering from chronic pain because of its long effect time.