Study of insulin resistance on oral mucosa disease and hepatitis C? role of a dentist

在日本，有200多万丙型肝炎病毒（HCV）感染者。丙型肝炎病毒感染是美国最大的传染病。另一方面，HCV可引起各种肝外表现和肝脏疾病。口腔扁平苔藓（OLP）、干燥综合征是肝外表现的代表性疾病。研究发现，HCV感染引起的胰岛素抵抗不仅与口腔癌有关，而且与多原发肿瘤有关。此外，我们澄清了以下问题：(1)延迟HCV感染患者干扰素（IFN）治疗开始的牙齿问题；(2)包括锌在内的支链氨基酸（BCAA）补充剂可改善HCV感染肝病患者对干扰素的敏感性；(3)在IFN治疗HCV相关慢性肝病期间和之后，念珠菌病和其他口腔粘膜病变；(4)日本HCV感染和OLP的回顾性病例对照研究。与HCV核心和N5A区突变的相关性研究。

In Japan, there are over two million hepatitis C virus (HCV) infected people. HCV infection is the nation's largest infection. On the other hand, HCV causes various kinds of extrahepatic manifestations as well as liver diseases. Oral lichen planus (OLP), Sjogren's syndrome are the representative diseases of extrahepatic manifestations. It was found that an insulin resistance that HCV infection caused was associatedwith not only oralcancerbut alsothemultipleprimaryneoplasm.Furthermore, we clarified follows: (1) Dental problems delaying the initiation of interferon (IFN) therapy for HCV-infected patients, (2) branched-chain amino acids (BCAA)-enriched supplementincludingzincimprovesthesensitivitytotasteinpatientswith HCV-infected liver disease, (3) Candidiasis and other oral mucosal lesions during and after IFN therapy for HCV-related chronic liver diseases, (4) A retrospective case-control study of HCV infection and OLP in Japan: association study with mutations in the core and N5A region of HCV.