Irreversible electroporation as a medical treatment without thermal damage to extracellular matrix

不可逆电穿孔（IRE）是一种通过在插入异常组织的两个电极之间施加高压来消融异常细胞的新方法。IRE的优点之一是细胞外基质（ECM）可以保持完整，这有利于愈合。因此，对于成功的IRE，重要的是使电极之间的细胞坏死，而不会因组织内的焦耳加热而对ECM造成热损伤。在本研究中，进行了三维（3-D）分析来预测IRE期间的温度上升。为了验证模拟结果，提出了一种利用温敏油墨测量瞬时温升的新方法。

The irreversible electroporation(IRE) is a novel method to ablate abnormal cells by applying a high voltage between two electrodes that are stuck into abnormal tissues. One of the advantages of the IRE is that the extracellular matrix(ECM) may be kept intact, which is favorable for healing. For a successful IRE, it is therefore important to necrotize cells between electrodes without thermal damage to ECM resulted from the Joule heating within the tissue. In the present study, threedimensional(3-D) analyses were conducted to predict temperature rise during the IRE. A new method for measuring instant temperature rise using temperaturesensitive ink was also developed for validating the simulated results.