课题基金 / 基金详情

Mechanism analysis of abacavir hypersensitivity

Mechanism analysis of abacavir hypersensitivity
阿巴卡韦过敏机制分析
批准号：
22659029
负责人：
SUZUKI Hiroshi
金额：
$2.02万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Challenging Exploratory Research
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2011
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22659029/
关键词：
薬剤反応性特異体質性毒性プロテオーム免疫応答HLAアバカビル生体分子薬理学

项目摘要

项目成果

SUZUKI Hiroshi的其他基金

相关文献

中文摘要
翻译
在与HLA-B* 5701基因突变相关的阿巴卡韦超敏反应中，强烈建议致病抗原不是先前假设的由蛋白质加合物衍生的肽，而是阿巴卡韦本身。在与阿巴卡韦过敏机制相同的其他病例中，现有的基于蛋白质加合物形成量的筛选系统无法发现不良反应的风险。结合新的筛选系统来鉴别药物或其代谢物是否作为抗原呈现，将提高特异性不良反应的预测准确性
英文摘要
In abacavir hypersensitivity associated with HLA-B* 5701 genecareers, it is strongly suggested that the causal antigen is not peptides derived from protein adducts, as is assumed previously, but the abacavir itself. In the other cases caused by the same mechanism with abacavir hypersensitivity, the existing screening system based on the amount of protein adducts formation cannot find out the risk of adverse effect. The combination with the new screening system to discriminate if the drugs or their metabolites are presented as antigen will improve the prediction accuracy of idiosyncraticadverse effect
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Usefulness of pre-hospital 12-lead electrocardiogram from K-ACTIVE registry
  • 批准号：
    20K08434
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.75万
  • 财政年份：
    2020
  • 负责人：
    SUZUKI Hiroshi
  • 依托单位：
    Showa University
Supply on the Houses for the Elderly with the Service to Take Out Self Support and Cooperation of the Elderly and the Community
  • 批准号：
    17K06733
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.0万
  • 财政年份：
    2017
  • 负责人：
    SUZUKI Hiroshi
  • 依托单位：
    Meijo University
Trial Production of Large Scale Nanofiber/Resin Film with Conductivity and Translucency by Applying Traveling Electric Field
  • 批准号：
    17K06061
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $3.08万
  • 财政年份：
    2017
  • 负责人：
    SUZUKI Hiroshi
  • 依托单位：
    Hachinohe Institute of Technology
Sharing the view of the earth from an extraterrestrial viewpoint-Internationalization of art expression technology using earth observation satellites-
  • 批准号：
    16K02318
  • 项目类别：
    Grant-in-Aid for Scientific Research (C)
  • 资助金额：
    $2.91万
  • 财政年份：
    2016
  • 负责人：
    SUZUKI Hiroshi
  • 依托单位：
    Kanazawa College of Art