Analysis of HDAC6-deficient mice that showing behavioral abnormalities related to psychiatric disorders

在这里，我们证明了Hdac6（组蛋白去乙酰化酶6）去乙酰化酶活性在小鼠情绪行为表达中的关键作用。此外，给予hdac6特异性抑制剂在小鼠中复制抗抑郁样作用。与Hdac6缺失小鼠的行为表型一致，Hdac6主要分布于中缝背核和中核，这两个区域与情绪行为有关。这些发现将有助于了解抑郁症的病因，并为抑郁症的治疗提供新的靶点。

Here we demonstrate the crucial roles of Hdac6(histone deacetylase 6) deacetylase activity in the expression of emotional behavior in mice. Moreover, administration of Hdac6-specific inhibitor replicated antidepressant-like effect in mice. In good agreement with behavioral phenotypes of Hdac6-deficient mice, Hdac6 dominantly localizes to the dorsal and median raphe nuclei, which are involved in emotional behaviors. These findings will help understand the etiology of depression, and provide a new therapeutic target for depression.