Development of environment benign synthetic process based on the enzymatic reaction using solid acid or base as a cooperative catalysis

对开发仲醇动态动力学分解（DKR）高效工艺进行了研究：通过脂肪酶催化的对映选择性酯交换反应和沸石介导的底物外消旋反应相结合，完成了所需的DKR反应。在沸石中，h - β - valfor CP8111BL-25为最佳外消旋催化剂，正己烷-离子液体为最佳溶剂体系。沸石介导的外消旋作用明显依赖于离子液体，在咪唑或季铵离子液体中外消旋作用顺利进行，而在磷盐离子液体中没有外消旋作用。离子液体包被脂肪酶PS （il - 1-PS）与h - β - valfor CP8111BL-25在二异丙醚溶剂体系中的结合效果良好，实现了芳基醇的高效DKR体系。

Investigation for developing the efficient process of dynamic kinetic resolution (DKR) of secondary alcohols has been conducted: the desired DKR reaction has been accomplished through the combination of lipase-catalyzed enantioselective transesterification and zeolite-mediated racemization of the substrates. Among zeolites evaluated, H-beta-VALFOR CP8111BL-25 was the best racemization catalyst and a mixed solvent system, hexane with ionic liquid was the suitable solvent system. Zeolite mediated racemization significantly depend on the ionic liquids, racemization proceeded smoothly in imidazolium or quaternary ammonium, while no racemization took place in phosphonium salts ionic liquids. It has also been established that a combination of ionic liquid coated lipase PS (IL1-PS) and H-beta-VALFOR CP8111BL-25 in diisopropyl ether solvent system afforded good results and achieved efficient DKR system of aryl alcohols.