Analyses of mechanisms regulating the traveling and splitting of stripe patterns

这项工作旨在阐明刺猬表达波的传播和分裂的分子机制，这是在蜘蛛胚胎中观察到的头部分割，这是一种新兴的模式节肢动物，属于螯角目。我们进行了胚胎RNA干扰筛选，以寻找敲低影响刺猬波表达行为的基因，并确定了犰狳和轴蛋白，它们被称为无翼信号的调节因子。详细的表型分析表明，犰狳活性的缺失阻止了刺猬波的动态行为，并使刺猬波的表达独立于正树突。我们的发现揭示了刺猬波传播和分裂的部分机制。

This work was aimed at elucidating molecular mechanisms underlying the traveling and splitting of a wave of hedgehog expression, which is observed for head segmentation in the embryo of the spider Parasteatoda tepidariorum, an emerging model arthropod that belongs to the Chelicerata. We carried out an embryonic RNA interference screen for genes whose knockdowns affected the behavior of the wave of hedgehog expression and identified armadillo and axin, which are known as regulators of wingless signaling. Detailed analyses of the phenotypes showed that the absence of armadillo activity prevented the hedgehog wave from behaving dynamically and made the hedgehog expression independent of orthodenticle. Our findings revealed a part of the mechanisms of hedgehog wave traveling and splitting.