Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistries

建立了一种新的高效合成具有抗肿瘤活性的海洋天然产物曲霉内酯A、B和C的方法。它也可以应用于各种相关化合物的合成，我们能够有一个独特的化合物库，从其中获得比天然产物具有更高生物活性的新分子。此外，成功地发明了一种能够富集和选择性标记生物活性化合物的靶蛋白以有效鉴定靶蛋白的LIPR4分子。

Novel and highly efficient methodology for the synthesis of marine-derived natural products aspergillides A, B and C with antitumor activity was developed. It can also be applied to the synthesis of a wide variety of related compounds and we were able to have a unique compounds library, from which a new molecule with higher biological activity than the natural products was obtained. In addition, a lariat molecule that enables enrichment and selective labeling of target proteins of the bioactive compounds for efficient identification of the target proteins was successfully invented.