Nested case-control study on the effects of prenatal exposure to PCBs

多氯联苯（PCBs）的环境暴露被认为是儿童神经行为发育的一个危险因素。进行巢式病例对照研究，以调查42个月的认知结果和产前暴露于PCB和DDE之间的关联。东北地区儿童发育研究队列包含在日本东部东北地区健康孕妇分娩时收集的脐带血样本。采用儿童考夫曼成套测验（K-ABC）进行认知功能评分。在调整了母亲智商、母亲年龄、妊娠天数、母亲鱼类摄入量、血浆omega-3/omega-6多不饱和脂肪酸等因素后，没有发现任何PCB和DDE与认知和同步处理评分有统计学显著相关性。

Environmental exposures to polychlorinated biphenyls (PCBs) have been suggested as a risk factor for neurobehavioral development in children. A nested case-control study was performed to investigate the association between the cognitive outcome at 42 months and the prenatal exposures to PCB and DDE. The Tohoku Study of Child Development cohort contains cord blood samples collected at the delivery of healthy pregnant women of the Tohoku district of east Japan. The cognitive score was assessed with the Kaufman Assessment Battery for Children (K-ABC). After adjusting with maternal IQ, maternal age, gestational days, maternal fish intake, plasma omega-3/omega-6 polyunsaturated fatty acids, and others, no statistically significant association with the cognitive and simultaneous processing scores was seen for any PCB and DDE.