Neural basis of human decision-making; Analysis in de novo Parkinson disease patients by neuroeconomic task

非药物治疗帕金森病患者腹侧纹状体和杏仁核活动对财务线索的干扰目的：本研究采用神经经济学任务结合功能磁共振成像，研究非药物治疗帕金森病患者行为反应背后的神经过程变化。方法：初发PD患者(n=9)和年龄匹配的健康对照组(n=8)执行改良的货币激励延迟任务。结果：初治PD患者腹侧纹状体和杏仁核对财务线索的反应活性降低。早期帕金森病患者可能表现出双重脑活动减少，包括构成大脑奖赏系统的腹侧纹状体活动不足和杏仁核功能障碍，这可能在损失厌恶中起关键作用。在帕金森病患者中，腹侧纹状体和杏仁核的功能障碍可能从发病时起就存在，并代表了多巴胺能治疗之前的一种行为内表型。

THE DISRUPTION OF VENTRAL STRIATUM AND AMYGDALA ACTIVITY TO FINANCIAL CUES IN NEVER-MEDICATED PARKINSON DISEASE PATIENTS.Objectives: This study investigated the altered neural processes underlying behavioral responses in never-medicated PD patients by using a neuroecomonics task in conjunction with functional magnetic resonance imaging. Methods: The de novo PD patients (n = 9) and age matched healthy controls (n = 8) performed a modified monetary incentive delay task. Results: The activity of ventral striatum and amygdala to financial cues was reduced in untreated de novo PD patients. PD patients in the early stage might show the dual reduced brain activities, including the hypoactivity of ventral striatum constituting the brain reward system and the dysfunction of amygdala that may play a key role in loss aversion. In PD, the dysfunction in ventral striatum and amygdala may be present from onset, and represent a behavioral endophenotype, prior to dopaminergic treatment.