toxicolgical role of Zn2+ in cell death induced by chemical stress

本文研究了Zn ~（2+）在化合物诱导细胞死亡中的毒理作用。微摩尔浓度的Zn ~（2+）可增强过氧化氢的细胞毒性，而胞内Zn ~（2+）的螯合剂可减弱过氧化氢的细胞毒性，这一结果表明Zn ~（2+）参与了过氧化氢诱导的细胞死亡。诱导细胞内Zn 2+浓度增加的化合物增强了过氧化氢的细胞毒性。然而，细胞内Zn 2+浓度的增加，由化合物升高的非蛋白质硫醇，细胞保护物质的细胞含量。结果表明，在一定条件下，Zn ~（2+）对细胞的死亡具有细胞保护和细胞毒性的交互作用。

The toxicological role of Zn2+ in cell death induced by chemical compounds was examined in this study. Micromolar concentrations of Zn2+ potentiated the cytotoxicity of hydrogen peroxide while the chelator of intracellular Zn2+ diminished it. This result suggests an involvement of Zn2+ in the cell death induced by hydrogen peroxide. The chemical compounds that induced the increase in intracellular Zn2+ concentration potentiated the cytotoxicity of hydrogen peroxide. However, the increase in intracellular Zn2+ concentration by the chemical compounds elevated the cellular content of nonprotein thiols, cytoprotective substances. It is suggested that Zn2+ exerts reciprocal actions, cytoprotective and cytotoxic, on the cell death under certain conditions.