Clarification of the natural host defense system against indigenous bacteria in alimentary tract

动物体内天然宿主防御本源细菌(IB)的研究成果如下：阐明IB在小肠和大肠的膜Toll样受体(MTLRs)/分泌性TLRs(STLRs)的关系，阐明IB的沉积变化与小肠杀菌物质分泌的关系，阐明肠道相关淋巴组织滤泡相关的肠腺中特殊的上皮细胞分化，阐明食道和表皮对IB过度增殖的宿主与上皮细胞凋亡的详细防御，证明了乳糜粒从肠上皮直接转运到肝门静脉血液和内皮细胞乳糜粒转运的受体，阐明了mTLRs的识别系统，并在呼吸道中分泌sTLRs对抗IB。

The research achievements on the natural host defense against indigenous bacteria (IB) in animals is as follows: the clarification of the relationship between IB settlement and membranous Toll-like receptor (mTLRs)/secretory TLRs (sTLRs) in small and large intestines, the clarification of the relationship between the alternation of IB settlement and the bactericidal substance secretion in small intestine, the clarification of the peculiar epithelial differentiation in the follicle-associated intestinal crypts of gut-associated lymphatic tissue, the clarification of the detailed host defense with epithelial apoptosis against IB hyperproliferation in esophagus and epidermis, the demonstration of the direct transportation of chylomicrons from the intestinal epithelium into the hepatic portal blood and the endothelial receptor for chylomicron transportation, the clarification of the recognition system with mTLRs and secretion of sTLRs against IB in the respiratory tract.