Synthesis the naphto[1,8-bc]furan and polycyclic heterocycles with good bioactivity.

多环杂环化合物以其刚性构象和对生物分子的高反应性而被称为优势化合物。由于这些化合物的高反应性，其合成极为困难。特别是萘[1,8-bc]呋喃环体系中含有大量的酶抑制剂，如虫马宁、烯喹酮和xestoquinone。通过烯基-2-卤-3-乙烯基-环己基-2-烯基醚的串联[4+2]环加成/芳构化序列，建立了核心环体系的合成路线。此外，还鉴定了多环杂环的抗增殖活性。

Polycyclic heterocycles were known as the privileged compound, and their structural features were consisted rigid conforamation and were highly-reactive to the biomolecules. It was extremely difficult for the synthesis of the compounds because of their high-reactivity. Particularly, the naphto[1,8-bc]furan ring system was consisted a lot of enzyme inhibitors, such as wortomanin, halenaquinone and xestoquinone. A convinced synthetic route for the core ring system was developed by tandem [4+2] cycloaddition/aromatization sequence of allenyl 2-halo-3-vinylcyclohex-2-enyl ethers. Furthermore, the antiproliferative activity by the polycyclic heterocycles was identified.