Targeting of mesenchymal stem cell associated with colorectal cancer liver metastasis

骨髓间充质干细胞（MSC）促进肿瘤的进展和转移，是肿瘤研究的前沿之一。我们报道了癌细胞分泌的HMGB1利用MSC进入肿瘤。它们的干性由HMGB1和含有tgf - β的多糖（一种癌症来源的细胞外基质）保留。这种组织状态经常在显微镜下观察到糖尿病合并结直肠癌转移到肝脏。HMGB1的吸收或中和会抑制利用MSC抑制肿瘤生长和转移。这些发现表明，靶向间充质干细胞可能是一种很有希望的抗癌方法。

Bone marrow-derived mesenchymal stem cell (MSC) enhances cancer progression and metastasis, which is one of cutting edges of cancer research. We reported that cancer cells-secreted HMGB1 employs MSC into tumors. Their stemness is retained by HMGB1 and TGF-beta-containing biglycan, which is cancer-derived extracellular matrix. This tissue status is often observed microscopically in diabetes-complicated colorectal cancer metastasizing to the liver. Absorbance or neutralization of HMGB1 inhibits employing MSC to suppress tumor growth and metastasis. These findings suggest that the targeting of MSC might be a promising method against cancer progression.