Ophthalmologic assessment of retinal vessels as a biomarker of the pharmacological response to antiangiogenic cancer chemotherapy

为了探索肿瘤化疗药物反应的生物标志物，包括血管生成抑制剂，本研究评估了137例接受肿瘤化疗的患者的视网膜血管的眼科表现。 视网膜血管直径;在对结直肠癌术前治疗有反应的患者中更有可能缩小;在难治性多发性骨髓瘤患者中清楚地反映了治疗效果;在转移性结直肠癌治疗期间获得长期稳定疾病的患者中显示出显著减少。

To explore biomarkers of the pharmacological response to cancer chemotherapy including angiogenic inhibitors, this research assessed ophthalmologic findings of retinal vessels of total 137 patients who receiving cancer chemotherapy. The retinal vessel diameters; were more likely to shrink in those who responded to the preoperative treatment of colorectal cancer; clearly reflected therapeutic efficacy in those with refractory multiple myeloma; and showed a marked reduction in those who obtained long-term stable disease during the treatment of metastatic colorectal cancer.