Head-out immersion in hot water increases serum levels of IL-6.

我们假设，头伸出热水浸泡（热应激）增加血清IL-6在人类。8名健康成年人分别进行了6项不同的测试，包括30分钟休息/20分钟干预/60分钟恢复，包括空气中休息（RA，室温28 ℃），在热中性期间休息（35.5C）浸水（RIN），在高温期间休息（42.0C）浸水（RIH），空气中锻炼（EA，在VO 2 max的60%下的测力计运动）、在热中性水浸泡（EIN）期间的运动和在热水浸泡（EIH）期间的运动。RIH和EIH均能增加浸泡过程中和浸泡后的中心温度和恢复期血清IL-6水平，且IL-6水平的增加幅度大于RA和RIN。运动并没有显著增加EA和EIN中的IL-6。EIH显著增加IL-6，尽管增加的幅度并不显著高于RIH。这些发现表明，热水浸泡通过增加身体核心温度而增加血清IL-6。

We hypothesized that head-out hot water immersion (heat stress) increases serum IL-6 in human. Each of 8 healthy adults performed 6 different tests of 30-min rest/20-min intervention/60-min recovery, including rest in air (RA, room temperature 28C), rest during thermoneutral (35.5C) water immersion (RIN), rest during hot (42.0C) water immersion (RIH), exercise in air (EA, ergometer exercise at 60% of VO2max), exercise during thermoneutral water immersion (EIN), and exercise during hot water immersion (EIH). RIH and EIH increased core temperature during and after the immersion and serum levels of IL-6 at recovery period, and the increase in IL-6 level was greater than in RA and RIN. Exercise did not significantly increase IL-6 in EA and EIN. EIH markedly increased IL-6, although the magnitude of the increase was not significantly higher than RIH. These findings demonstrated that hot water immersion increases serum IL-6 through increased body core temperature.