Developmental reserch of the novel therapy for intractable pulmonary diseases such as pulmonary fibrosis

恶性胸膜间皮瘤(MPM)是一种侵袭性间皮源性恶性肿瘤，对常规化疗和放射治疗反应有限。因此，早期诊断MPM非常重要。我们发现MPM患者的某些标志物如HMGB1、硫氧还蛋白、血管生成素-1的水平显著高于接触石棉但未发生MPM的人群。血清HMGB1和Angiopoietin-1水平低于和高于假定的临界值的两组患者的总生存率差异显著，提示血清HMGB1、硫氧还蛋白和Angiopoietin-1水平是MPM有用的临床标志物。

Malignant pleural mesothelioma (MPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to conventional chemotherapy and radiotherapy. Therefore, diagnosing MPM early is very important. We demonstrated that patients with MPM had significantly higher serum levels of some markers such as HMGB1, thioredoxin, angiopoietin-1 than the population who had been exposed to asbestos but had not developed MPM. The difference in overall survival between groups with serum HMGB1 and angiopoietin-1 levels that were lower and higher than assumed cut-off values was significant.Our data suggest that serum HMGB1, thioredoxin and angiopoietin-1 concentrations are useful clinical markers for MPM.