Neuronal metabolic changes in preterm infants assessed using multi-voxel proton magnetic resonance spectroscopy

本研究旨在揭示正常发育和精神运动迟缓的早产儿和低出生体重儿一岁内脑代谢变化的差异。我们招募了17名在妊娠29周出生的婴儿，体重为1108克。分别于妊娠后39 ~ 46周、47 ~ 60周、75 ~ 89周和90 ~ 104周行MRS检查。经额叶（FL）、基底节区和丘脑（BG+Th）行MRS。测定n -乙酰天冬氨酸(NAA)/肌酸（Cr）、胆碱/Cr和肌醇(Ins)/Cr。DQ、MRI正常患儿13例作为对照组。4例MRI表现异常的婴儿被归类为试验对象。发育迟缓被试BG+Th的NAA/Cr在61 ~ 74pcw低于对照组平均值的-2SD， Ins/Cr在90 ~ 104pcw高于对照组平均值的+2SD。

This study aimed to reveal the difference of brain metabolic change using MRS within the first year of life between normal development and psychomotor retardation in preterm and low birth weight infants.We enrolled 17 infants who were born at 29 weeks gestation weighing 1,108g.They underwent MRS at 39-46 postconceptional weeks(PCW),47-60PCW,75-89PCW,and 90-104PCW.MRS was performed through the frontal lobe(FL)and the basal ganglia and thalamus(BG+Th).N-acetylaspartate(NAA)/creatine(Cr),choline/Cr and myoinositol(Ins)/Cr were determined.Thirteen infants had normal DQ and MRI were formed the contral group.Four infants had abnormalitied on MRI were classified as test subjects.The NAA/Cr in the BG+Th of two test subjects who were developmental delay was below -2SD of the mean of the controls from 61-74PCW and Ins/Cr was above +2SD at 90-104PCW.