Evaluation of vascular smooth muscle cell function and response mechanism according to transformation from constitution type to secretion type in acute phase of vasculitis

我制作了一个类似于川崎病的血管炎动物模型，并阐明了血管平滑肌细胞通过内弹性带的破坏而从中膜迁移，同时在内皮下部位发生组织学上的血管炎。迁移到内皮下部位的血管平滑肌细胞通过转录因子的表达从组成型转化为分泌型的可能性，KLF 5和Egr-1。但对转化后的血管平滑肌细胞的功能和反应机制还没有足够的估计。

I made a vasculitis animal model of the Kawasaki disease resemblance,and elucidated migration of a vascular smooth muscle cell from a media by the destruction of the inner elasticity band with a vasculitis histologically in the subendothelial site.Furthermore, the possibility that the vascular smooth muscle cell which migrated in the subendothelial site was transformed in a secretion type from a constitution type by the expression of transcriptional factors such as KLF5 and Egr-1 was suggested. But enough estimation was not accomplished about the function and response mechanism of a transformed vascular smooth muscle cell.