Does fibronectin activated by dermatopontin have anti-tumor activity?

我们发现皮肤桥蛋白与纤维连接蛋白相互作用并激活它（Kato， J. Biol.）。Chem. 2011, Okamoto, Astetic Dermatol. 2011)。激活的纤维连接蛋白减少了小鼠背上接种黑色素瘤的血管数量。我们还发现皮肤桥蛋白与纤维蛋白原相互作用。皮桥蛋白加速纤维蛋白原纤维的形成，新形成的纤维蛋白原纤维的直径比正常情况下形成的纤维蛋白原纤维的直径大。纤维蛋白原纤维增强人脐静脉内皮细胞粘附和细胞扩散(Wu， J. Invest；北京医学,2014)。

We found that dermatopontin interacts with fibronectin and activates it (Kato, J. Biol. Chem. 2011, Okamoto, Astetic Dermatol. 2011). The activated fibronectin decreased the number of vessels in melanoma tumor inoculated on the back of mice.We also found that dermatopontin interacts with fibrinogen. Dermatopontin accelerated fibrin fibril formation and the diameters of newly-formed fibrin fibrils became greater than those formed under normal condition. The fibrin fibrils enhanced human umbilical vein endothelial cell adhesion and the cell spreading (Wu, J. Invest. Dermatol. 2014).